Table 1.

Definition of groups for each experiment

Experiment	Group 1	Group 2
1. Astrocytoma vs astrocytosis	Group 1 from experiment 3 (79 cases, 770 image files)	Nontumoral, reactive brain tissue (47 cases, 286 image files)
2. Glioma vs brain metastasis	Group 1 and 2 from experiment 3 (121 cases, 1216 image files)	Brain metastases (57 cases, 577 image files)
3. Prediction of 1p/19q-status in IDH-mutant tumors	IDH-mutant astrocytomas (grades II-III) and IDH-mutant glioblastomas (79 cases, 770 image files)	IDH-mutant, 1p/19q co-deleted oligodendrogliomas (grades II-III) (42 cases, 446 image files)
4. Negative control experiment: even vs odd accession numbers	Even accession number (26 cases, 251 image files)	Odd accession number (25 cases, 249 image files)
5. Negative control experiment: astrocytoma vs astrocytoma	Random selection of half of the images of cases from group 1 in experiment 3 (67 cases, 335 images)	Other half of images from the same cases as in group 1 (67 cases, 335 images)