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. 2023 Jan 2;82(3):250–260. doi: 10.1093/jnen/nlac123

Figure 2.

Figure 2.

Histopathology of the initial DPedHGG, MYB::QKI fusion-positive tumor. (A, B) The tumor is composed of angiocentric astrocytic cells. The angiocentric areas are myxoid. (C) p53 is strongly positive in the tumor cell nuclei. (D) Ki-67 labeling index is 16.2%. (E) Histopathology of the recurrent tumor shows sheet-like growth of elongated glial cells with angiocentric whirling. (F) Pleomorphic nuclei of tumor cells and necrosis are observed. (G) GFAP is positive in the tumor cells (negative area: blood vessels). (H) c-MYB immunostain is positive in the tumor cell nuclei. (I) The Ki-67 (MIB-1) labeling index is high (69.4%) (A, B, E, F: HE, C: p53, D, I: Ki-67 immunohistochemistry, G: GFAP, H: c-MYB. Scale bars: A: 200 µm, B–D: 200 µm, E–G: 50 µm, H, I: 100 µm).