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. 2022 Oct 29;32(5):873–882. doi: 10.1093/hmg/ddac269

Figure 2.

Figure 2

Workflow to identify novel SNP associations with CD, UC and IBD. This is an overview of the workflow used in determining new risk loci in the IBD trans-ancestry meta-analysis. Summary statistics from EUR, EA and AA cohorts were combined using MANTRA for each of the phenotypes of interest (UC, CD and IBD). The left-hand side of the figure depicts the common SNPs carried over in the downstream analysis for the EUR, EAS and AA trans-ancestry meta-analysis. The right-hand side of the figure displays the common SNPs carried over in the downstream analysis for the EUR and AA trans-ancestry meta-analysis. SNPs with a log 10 Bayes Factor ≥ 6 were considered to be genome-wide significant. Variants within 500 Kb of established risk loci for the IBD phenotype of interest or in the MHC region were removed from the analysis.