Table 1. Baseline Demographic and Clinical Characteristics of 150 Randomized Participantsa.
| Characteristic | Placebo group (n = 73) | Simvastatin group (n = 77) |
|---|---|---|
| Age, median (IQR), y | 35 (31-41) | 40 (30-45) |
| Sex at birth | ||
| Male | 33 (45) | 34 (44) |
| Female | 40 (55) | 43 (56) |
| Educational level, median (IQR), y | 8.0 (3.0-10.0) | 8.0 (0.0-10.0) |
| Marital status | ||
| Single | 14 (19) | 9 (12) |
| Married | 56 (77) | 62 (81) |
| Divorced or widowed | 3 (4) | 6 (8) |
| Household status | ||
| Lives alone | 33 (45) | 43 (56) |
| Lives with family members | 40 (55) | 34 (44) |
| No. in family, median (IQR) | 7 (5-10) | 7 (5-9) |
| Household income, median (IQR), Rs | 25 000 (16 000-40 000) | 25 000 (16 000-40 000) |
| Socioeconomic status | ||
| Lower | 40 (55) | 42 (55) |
| Middle or upper | 33 (45) | 35 (45) |
| BMI, median (IQR) | 27.4 (24.9-30.6) | 26.7 (22.7-30.1) |
| Height, median (IQR), m | 1.57 (1.52-1.65) | 1.63 (1.52-1.65) |
| Smoker | ||
| No | 62 (85) | 67 (87) |
| Yes | 11 (16) | 10 (13) |
| Blood pressure, median (IQR), mm Hg | ||
| Systolic | 120 (120-130) | 120 (118-130) |
| Diastolic | 80 (80-90) | 80 (70-80) |
| No. of psychiatric hospitalizations | ||
| 0 | 52 (71) | 62 (81) |
| 1 | 13 (18) | 9 (12) |
| ≥2 | 8 (11) | 6 (7.8) |
| Duration of current depressive episode, median (IQR), mo | 5 (3-10) | 5 (3-7) |
| No. of psychotropic medications | ||
| 1 | 25 (34) | 30 (39) |
| 2 | 30 (41) | 33 (43) |
| 3 | 16 (22) | 13 (17) |
| 4 | 2 (3) | 1 (1) |
| MADRS score, median (IQR) | 29 (24-34) | 27 (23-33) |
| HamD-24 score, median (IQR) | 31 (26-34) | 30 (27-34) |
| GAD-7 score, median (IQR) | 14 (12-16) | 13 (11-15) |
| MMAS-4 score | ||
| 0 | 46 (63) | 42 (55) |
| 1 | 11 (15) | 14 (18) |
| 2 | 8 (11) | 10 (13) |
| 3 | 3 (4) | 4 (5) |
| 4 | 5 (7) | 7 (9) |
| CRP, median (IQR), mg/L | 1.39 (1.39-1.87) | 1.39 (1.39-1.76) |
| Cholesterol, median (IQR), log mg/dL | ||
| HDL-C | 3.78 (3.69-3.85) | 3.76 (3.69-3.83) |
| LDL-C | 4.91 (4.66-5.04) | 4.84 (4.68-4.99) |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); CRP, C-reactive protein; GAD-7, 7-item Generalized Anxiety Disorder Scale; HamD-24, 24-item Hamilton Rating Scale for Depression; HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; MADRS, Montgomery-Åsberg Depression Rating Scale; MMAS-4, Morisky Medication Adherence Scale (4-item); R, rupees.
SI conversion factors: To convert cholesterol to milligrams per deciliter, multiply by 0.0259; and CRP to milligrams per liter, multiply by 10.
a
Data are presented as number (percentage) unless otherwise indicated.