Table 3.
Odds ratios of clinical deficit associated with prenatal anesthetic exposure
| Likely exposed to general anesthetic during pregnancy |
No report of exposure to general anesthetic during pregnancy |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Neuropsychological domain | Outcome | Score | Total (n) | Deficit (n) | Deficit (%) | Total (n) | Deficit (n) | Deficit (%) | Adjusted ORa (99.17% CI) | P-valuea |
|
| ||||||||||
| Language | CELF | Total | 19 | 0 | 0 | 1600 | 242 | 15.1 | - | - |
| Receptive | 19 | 0 | 0 | 1600 | 220 | 13.8 | - | - | ||
| Expressive | 19 | 2 | 10.5 | 1600 | 254 | 15.9 | 0.5 (0.1 , 3.5) | 0.31 | ||
| PPVT | Standard | 18 | 3 | 16.7 | 1482 | 234 | 15.8 | 0.9 (0.2 , 5.3) | 0.93 | |
| Cognition | CPM | Total | 19 | 3 | 15.8 | 1601 | 256 | 16 | 0.8 (0.1 , 4.2) | 0.67 |
| SDMT | Written | 19 | 0 | 0 | 1591 | 209 | 13.1 | - | - | |
| Oral | 19 | 2 | 10.5 | 1591 | 249 | 15.7 | 0.6 (0.1 , 4.2) | 0.45 | ||
| Motor function | MAND | NDI | 18 | 7 | 38.9 | 1584 | 266 | 16.8 | 3.2 (0.9 , 12.2) | 0.019 |
| Behavior | CBCL | Total | 22 | 8 | 36.4 | 1967 | 264 | 13.4 | 3.4 (1.0 , 11.6) | 0.009 |
| Externalizing | 22 | 8 | 36.4 | 1967 | 206 | 10.5 | 4.6 (1.3 , 16.0) | 0.001b | ||
| Internalizing | 22 | 7 | 31.8 | 1967 | 283 | 14.4 | 2.5 (0.7 , 8.8) | 0.05 | ||
a
Adjusted for demographic and clinical covariates (sex, race, maternal school level, income, alcohol or tobacco use during pregnancy, and presence of any maternal clinical diagnoses: diabetes, epilepsy, heart disease, psychiatric disorders, or thyroid dysfunction)
b
Statistically significant at p<0.0083