Table 4.

Mediation analyses of CBCL Externalizing scores using complete cases

	Mediators
	Prematurity Estimate (95% CI)	Birth weight <2500gm Estimate (95% CI)	Intrauterine growth retardation Estimate (95% CI)	C-section Estimate (95% CI)	Epidural anesthesia Estimate (95% CI)	Post-natal surgery Estimate (95% CI)
Total Effect (score difference)	6.68 (1.54 , 11.82)	6.57 (1.53 , 11.62)	6.51 (−2.14 , 15.15)	6.88 (1.15 , 12.61)	6.67 (1.19 , 12.15)	6.99 (2.19 , 11.79)
Direct Effect	6.66 (2.04 , 11.28)	6.63 (2.01 , 11.26)	6.45 (0.10 , 12.8)	4.86 (0.10 , 9.63)	4.86 (0.05 , 9.67)	7.06 (2.42 , 11.7)
Indirect Effect	0.02 (−2.26 , 2.29)	−0.06 (−2.1 , 1.98)	0.06 (−2.97 , 3.08)	2.02 (−1.62 , 5.65)	1.81 (−1.43 , 5.06)	−0.07 (−1.35 , 1.21)
Percent Mediated	0.2 (−33.7 , 34.2)	−0.9 (−32.2 , 30.4)	0.9 (−44.6 , 46.4)	29.3 (−14.8 , 73.4)	27.2 (−15.3 , 69.6)	−1.0 (−19.5 , 17.4)
Percent due to Interaction	16.7 (−16.3 , 49.6)	16.2 (−16.1 , 48.6)	2.3 (−114.9 , 119.5)	73.1 (4.8 , 141.3)	115.3 (−5.6 , 236.2)	−17.2 (−51.1 , 16.8)

Analyses of all mediators except for prematurity were adjusted for sex, race, maternal school level, income, alcohol or tobacco use during pregnancy, and presence of any maternal clinical diagnoses: diabetes, epilepsy, heart disease, psychiatric disorders, or thyroid dysfunction. The prematurity analysis was adjusted for all covariates except for maternal heart disease.