Table 3. Caucasian convalescent donor HLA allele frequency comparison with the NMDP database for HLA*A, B, C, DRB1 and DQB1. The g notation specifies G-groups corresponding to those presented in Gragert, Loren, Abeer Madbouly, John Freeman, and Martin Maiers. Six-locus high resolution HLA haplotype frequencies derived from mixed-resolution DNA typing for the entire US donor registry. Human Immunology 74, no. 10.
| Loci | Alleles | Observed frequency (2n = 180) | CI 95% | NMDP frequency | Adjusted p-value |
|---|---|---|---|---|---|
| HLA-A | 02:01G | 0,267 | [0.204–0.338] | 0,272 | 1,000 |
| 01:01G | 0,122 | [0.078–0.179] | 0,159 | 1,000 | |
| 03:01G | 0,117 | [0.074–0.173] | 0,140 | 1,000 | |
| 24:02G | 0,072 | [0.039–0.120] | 0,089 | 1,000 | |
| 29:02G | 0,061 | [0.031–0.107] | 0,031 | 0,427 | |
| 11:01G | 0,061 | [0.031–0.107] | 0,059 | 1,000 | |
| HLA-B | 44:02G | 0,128 | [0.083–0.186] | 0,087 | 1,000 |
| 07:02G | 0,089 | [0.052–0.140] | 0,125 | 1,000 | |
| 08:01G | 0,083 | [0.047–0.134] | 0,106 | 1,000 | |
| 44:03 | 0,072 | [0.039–0.120] | 0,044 | 1,000 | |
| 40:01G | 0,067 | [0.035–0.114] | 0,050 | 1,000 | |
| 18:01G | 0,061 | [0.031–0.107] | 0,047 | 1,000 | |
| 35:01G | 0,061 | [0.031–0.107] | 0,058 | 1,000 | |
| 27:05G | 0,056 | [0.027–0.100] | 0,035 | 1,000 | |
| HLA-C | 05:01G | 0,1389 | [0.092–0.198] | 0,083 | 0,109 |
| 04:01G | 0,1222 | [0.078–0.179] | 0,115 | 1,000 | |
| 07:01G | 0,1167 | [0.078–0.179] | 0,155 | 1,000 | |
| 06:02G | 0,0944 | [0.056–0.147] | 0,095 | 1,000 | |
| 07:02G | 0,0944 | [0.056–0.147] | 0,137 | 1,000 | |
| 02:02G | 0,0889 | [0.052–0.140] | 0,047 | 0,138 | |
| 12:03G | 0,0722 | [0.039–0.120] | 0,056 | 1,000 | |
| 03:04G | 0,0667 | [0.035–0.114] | 0,074 | 1,000 | |
| HLA-DRB1 | 07:01 | 0,178 | [0.125–0.242] | 0,130 | 1,000 |
| 01:01 | 0,100 | [0.060–0.153] | 0,085 | 1,000 | |
| 03:01 | 0,089 | [0.052–0.140] | 0,114 | 1,000 | |
| 04:01 | 0,089 | [0.052–0.140] | 0,080 | 1,000 | |
| 13:01g | 0,083 | [0.047–0.134] | 0,000 | 0,000 | |
| 15:01 | 0,078 | [0.043–0.127] | 0,129 | 0,985 | |
| 11:01g | 0,056 | [0.027–0.100] | 0,063 | 1,000 | |
| 14:01g | 0,056 | [0.027–0.100] | 0,027 | 0,497 | |
| HLA-DQB1 | 02:01g | 0,211 | [0.154–0.278] | 0,212 | 1,000 |
| 03:01g | 0,200 | [0.144–0.266] | 0,196 | 1,000 | |
| 05:01 | 0,133 | [0.087–0.192] | 0,116 | 1,000 | |
| 06:03g | 0,089 | [0.052–0.140] | 0,065 | 1,000 | |
| 06:02 | 0,078 | [0.043–0.127] | 0,128 | 0,621 | |
| 03:02g | 0,067 | [0.035–0.114] | 0,103 | 1,000 | |
| 03:03g | 0,056 | [0.027–0.100] | 0,043 | 1,000 | |
| 05:03g | 0,056 | [0.027–0.100] | 0,029 | 0,407 |
Alleles with less than 10 data points are not shown.
NDMP: National Marrow Donor Program.