Procedures in efficacy (active pediatric cohort)	Census and clustering Months −10 to −4	Enrollment/baseline(E) Visit 1, day 1	Study visit 2(E) Day 31 +/−3 days	Study visit 3(E) Day 61 +/− 3 days	Study visit 4(E) Day 91 +/−3 days	Study visit 5(E) Day 121 +/−3 days	Study visit 6(E) Day 151 +/−3 days	Study visit 7(E) Day 181 +/−3 days
Informed consent for census	X
Demographic data collection	X
Randomization	X
Informed consent		X
Anthropometry		X			X			X
Review infant vaccination card		X			X			X
Complete visit template		X	X	X	X	X	X	X
Malaria RDT		X	X	X	X	X	X	X
Malaria treatment a		X	X	X	X	X	X	X
Assessment of selected NTDs		X	X	X	X	X	X	X
COVID responseb		X	X	X	X	X	X	X
Malaria parasite immune response samples b		X	X	X	X	X	X	X
Plasmodium PCR for quality control and molFOIc		X	X	X	X	X	X	X
Passive incidence surveillance at health facilities (all ages)		X-------------------------------------------------------X

^aOnly if RDT is positive (see case definition)

^bOnly in a randomly selected sub-sample

^cOnly in a randomly selected 10% sub-sample