Skip to main content
. 2023 Jan 28;26(2):106080. doi: 10.1016/j.isci.2023.106080

Figure 1.

Figure 1

Mass spectrometric identification and verification of an AMG510 covalently modified peptide from KRAS/G12C protein

(A) MS/MS spectrum of the triply charged synthetic peptide (LVVVGACGVGK∗, ∗denote heavy isotope) covalently modified by AMG510 (left) and the extracted ion chromatograms (XICs) showing the retention times of free and modified peptides (right). Inset shows the precursor ion mass.

(B) MS/MS spectrum of the AMG510-modified LVVVGACGVGK from trypsin digested recombinant KRAS/G12C protein (left) and XICs of the free and modified peptides (right).