Table 8. Flow System Developed for Alkene Epoxidation with Mn(OAc)2.
| substrate | Mn(OAc)2 loading (mol%) | 2-picolinic acid loading (mol%) | conv. (%)a | yield (%)a |
|---|---|---|---|---|
| cycloocteneb | 0.05 | 1 | 100 | 83 (76d) |
| 1-octeneb | 0.05 | 1 | 100 | 78e |
| styreneb | 0.05 | 1 | 32 | 26 |
| styrenec | 0.2 | 4 | 93 | 63 |
a
Determined by GC with an internal standard (benzonitrile, which is in the substrate feed).
b
5.5 mM Mn(OAc)2 solution in MeOH and 11 mM 2-picolinic acid solution in MeCN.
c
22 mM Mn(OAc)2 solution in MeOH and 44 mM 2-picolinic acid solution in MeCN.
d
Isolated yield.
e
Consistently obtained over 8 h of operation.