Table 1. Yields of Isolated Piperazines 2.
Entry | X | R1 | R2 | Product | Yield (%) |
---|---|---|---|---|---|
1 | Br | H | COMe | 2a | 80 |
2 | Br | H | CO2tBu | 2b | 55 |
3 | Br | H | F | 2c | 30 |
4 | Br | H | CF3 | 2d | 34 |
5 | Br | H | CN | 2e | 70 |
6 | Br | H | Cl | 2f | 25 |
7 | I | H | H | 2g | 30 |
8 | I | H | F | 2c | 55 |
9 | I | H | Cl | 2f | 58 |
10 | I | H | Cl | 2f | 48a |
11 | I | OMe | H | 2h | 42 |
12 | I | H | Me | 2i | 35 |
Using 4CzIPn as photocatalyst.