Figure depicts the age at diagnosis for individual colorectal cancers specifically, stratified by gene group (MSH6 vs. PMS2), overall (blue), which includes all tumors (MMR-D/MSI-H, MMR-P/MSS, and untested/unknown tumors), and for MMR-D/MSI-H tumors (gray) in patients with P/LP variants in MSH6 or PMS2. The red line depicts age = 35, the upper limit of guideline recommendations for initiation of surveillance colonoscopies.