Table 1:
Patient Characteristics
| Variables | Overall (N=243) | MSH6 (N=148) | PMS2 (N=95) | p-valueb |
|---|---|---|---|---|
| Sex | ||||
| Male | 96 (40%) | 57 (39%) | 39 (41%) | 0.69 |
| Female | 147 (60%) | 91 (61%) | 56 (59%) | |
| Age at 1st cancer diagnosisa (median, range) | ||||
| Male | 53.5 (15–84) | 51.5 (15–84) | 54.5 (28–80) | 0.71 |
| Female | 53 (1–88) | 53 (27–88) | 51 (1–81) | 0.85 |
| Self-Reported Race/Ethnicity | ||||
| Non-Hispanic-White | 209 (86%) | 134 (90%) | 75 (79%) | 0.075c |
| Black | 14 (6%) | 5 (3%) | 9 (10%) | |
| Asian | 10 (4%) | 5 (3%) | 5 (5%) | |
| Other | 2 (1%) | 1 (1%) | 1 (1%) | |
| Hispanic | 5 (2%) | 1 (1%) | 4 (4%) | |
| Unknown | 3 (1%) | 2 (2%) | 1 (1%) | |
| Ashkenazi Jewish Ancestry | 42 (17%) | 38 (26%) | 4 (4%) | <0.001 |
| Body Mass Index (BMI) kg/m2 at study enrollment (median, range) | ||||
| Male | 26.7 (17.6–39.8) | 27.6 (17.6–39.8) | 26.0 (21.5–39.2) | 0.13 |
| Female | 25.3 (15–52.8) | 25.1 (18.4–52.8) | 25.7 (15–51.9) | 0.51 |
| Smoking Status | ||||
| Ever smoker | 67 (28%) | 41 (28%) | 26 (27%) | 0.502 |
| Never smoker | 142 (58%) | 80 (54%) | 62 (65%) | |
| Unknown/Missing | 34 (34%) | 27 (18%) | 7 (8%) | |
a
In cancer-affected patients only.
b
p-values are chi-squared/fisher’s exact or ranksum.
c
p=0.011 when comparing white to non-whites
Table depicts clinical characteristics for all patients overall and by gene (MSH6 and PMS2).