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. 2023 Feb 20;21:64. doi: 10.1186/s12916-023-02757-2

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Associations between age at menarche in combination with age at menopause and reproductive span and the risk of cardiovascular events. HR, hazard ratio adjusted for cardiovascular risk factors (income, smoking, alcohol consumption, regular exercise, body mass index, systolic blood pressure, total cholesterol, fasting glucose, hypertension, diabetes mellitus, and dyslipidemia) and reproductive factors (parity, duration of breast feeding, duration of hormone replacement therapy, and duration of oral contraceptive use); CI, confidence interval, a) the association of combined reproductive factors with myocardial infarction. b) the association of combined reproductive factors with ischemic stroke