Table 2.
Sensitivity and specificity of HS-RDT and co-RDT, and paired t-test comparisons in each study
| Study | Sensitivity | Specificity | Parasite Density Geometric mean (0.95CI) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HS-RDT mean (0.95 CI) | Co-RDT mean (0.95 CI) | P value | HS-RDT mean (0.95 CI) | Co-RDT mean (0.95 CI) | P value | Reference method | HS-RDT + co-RDT - | HS-RDT | co-RDT | |
| Benin | 60.5 (52.7–67.8) | 44.2 (36.9–51.9) | 0.004 | 93.6 (91.7–95.3) | 95.7 (94.0–97.0) | 0.65 | 71.2 (47.0–107.9) | 20.7 (10.8–39.6) | 179.1 (108.3–296.2) | 532.0 (324.0–874.0) |
| Colombia (1) | 85.7 (70.6–93.7) | 82.8 (67.3–91.9) | 0.74 | 99.4 (98.5–99.8) | 99.9 (99.2–100.0) | 0.94 | ||||
| Colombia (2) | 64.1 (47.2–78.8) | 53.8 (37.2–69.9) | 0.38 | 99.9 (99.3–100.0) | 100.0 (99.6–100.0) | 0.99 | 13.2 (4.4–39.0) | 119.2 (58.0–244.70) | 200.1 (114.4–350.0) | |
| Indonesia | 19.6 (13.9–26.8) | 22.8 (16.7–30.3) | 0.51 | 98.2 (93.1–99.7) | 95.5 (89.4–98.3) | 0.50 | ||||
| Kenya | 54.7 (46.9–62.2) | 49.4 (41.7–57.1) | 0.34 | 95.8 (92.9–97.8) | 96.1 (93.3–98.0) | 0.94 | 43.0 (33.0–58.0) | 103.0 (69.0–153.0) | ||