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. 2023 Feb 20;21:65. doi: 10.1186/s12916-023-02766-1

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Distinctive gene expression trajectories over time for different causes of IS based upon self-organizing maps (SOM). DEG trajectories across time (0 h, 0–24 h, >24 h)) are shown for cardioembolic (CE), large vessel (LV), and small vessel (SV) causes of strokes in monocytes, neutrophils, and whole blood. Dots on each profile represent every time point from left to right. Rows show similar expression profiles across stroke etiology in each sample type; empty cells indicate no matching profile was found in that sample type / etiology combination. The top enriched Gene Ontology (GO) terms for biological processes are shown for each profile. The color corresponds to the percentage of genes in the GO group present in the profiles. Abbreviations: Ag: antigen; reg: regulation; diff: differentiation; neg.: negative; pos.: positive; prom: promoter; R: receptor; recomb: recombination; RNP: ribonucleoprotein; sec.: secretion; S.: signal/signaling; TLR: Toll-like receptor; transduc: transduction; transmemb.: transmembrane