Table 1.
Subject demographics and relevant clinical characteristics in each of the time windows analyzed
| IS | |||||
|---|---|---|---|---|---|
| VRFC | 0–24 h (TP1) | 24–48 h (TP2) | >48 h (TP3) | ||
| Monocytes | Subjects | 12 | 17 | 13 | 5 |
| Age, years (mean ±SD) | 62.08±6.70 | 68.41±11.88 | 61.46±12.51 | 66.60±8.04 | |
| Time since event, h (mean ±SD) | nil | 15.67±5.26 | 32.37±8.51 | 56.02±9.80 | |
| NIHSS at admission (mean ±SD) | 0±0 | 4.94±5.40 | 2.92±4.51 | 3±2.16a | |
| NIHSS at blood draw (mean ±SD) | 1.6±3.57 | 3±4.27 | 1.76±4.08 | 1.75±0.95 | |
| Sex (male; female) (n) | 6; 6 | 10; 7 | 8; 5 | 0; 5 | |
| Diabetes (n) | 6 | 3 | 2 | 1 | |
| Hyperlipidemia (n) | 10 | 6a | 7 | 3 | |
| Hypertension (n) | 6 | 13 | 10 | 5 | |
| Neutrophils | Subjects | 12 | 16 | 12 | 5 |
| Age, years (mean ±SD) | 64.66±11.34 | 68.5±12.26 | 61.50±13.06 | 66.60±8.04 | |
| Time since event, h (mean ±SD) | nil | 16.25±4.84 | 31.21±7.74 | 56.02±9.80 | |
| NIHSS at admission (mean ±SD) | 0±0 | 4.62±5.41 | 3.08±4.67 | 3±2.16 | |
| NIHSS at blood draw (mean ±SD) | 2.25±3.86 | 3.18±4.33 | 1.83±4.26 | 1.75±0.95 | |
| Sex (male; female) (n) | 6; 6 | 9; 7 | 7; 5 | 0; 5 | |
| Diabetes (n) | 6 | 3 | 1 | 1 | |
| Hyperlipidemia (n) | 10 | 6a | 6 | 3 | |
| Hypertension (n) | 9 | 13 | 9 | 5 | |
| Whole blood | Subjects | 18 | 18 | 13 | 6 |
| Age, years (mean ±SD) | 64.83±9.401 | 68.88±11.70 | 63.15±11.23 | 65.66±7.55 | |
| Time since event, h (mean ±SD) | nil | 15.53±5.14 | 32.41±8.47 | 62.00±17.07 | |
| NIHSS at admission (mean ±SD) | 0±0 | 4.72±5.32 | 2.92±4.51 | 3.20±1.92 | |
| NIHSS at blood draw (mean ±SD) | 1.8±3.49 | 3±4.27 | 1.92±4.05 | 1.8±0.83 | |
| Sex (male; female) (n) | 10; 8 | 11; 7 | 7; 6 | 0; 6a | |
| Diabetes (n) | 7 | 4 | 3 | 1 | |
| Hyperlipidemia (n) | 14 | 7a | 6 | 4 | |
| Hypertension (n) | 11 | 14 | 10 | 6 | |
aSignificant difference vs. VRFC (p-value < 0.05, Fisher’s exact probability test—categorical variables, Student’s t test—continuous variables) NIHSS scale range is from 0 to 43. Less than half of VRFC had NIHSS assessed. For the rest of time points 80–100% of patients had NIHSS data