Table 3.

Role of m6A regulator in radiotherapy and immunotherapy

Drug	Regulator	Role	Level	Cancer	Target	Effect	Refs.
irradiation	METTL3	Oncogene	High	GBM	Pol kappa	regulates its localization to DNA damage sites	[130]
irradiation	METTL3	Oncogene	High	GBM	SOX2	Increases stability of SOX2 mRNA	[131]
irradiation	FTO	Oncogene	High	CSCC	β-catenin	Promotes expression of β-catenin	[132]
irradiation	ALKBH5	Oncogene	High	GBM	CHK1, Rad51	Promotes expression of CHK1 and Rad51	[133]
Anti-PD1	METTL3/14	Oncogene	High	CRC	STAT1, IRF1	stabilizing the STAT1 and IRF1 mRNA via YTHDF2 [135]	[135]
Anti-PD1	METTL14	Suppressor	NA	CCA	SIAH2	Promotes the degradation of SIAH2 mRNA via YTHDF1	[136]
Anti-PD1	YTHDF1	Oncogene	NA	Melanoma	cathepsins	Promotes the translation of lysosomal cathepsins	[137]
Anti-PD1	FTO	Oncogene	High	Melanoma	PD-1, CXCR4, SOX10	Reduces the degradation of PD-1, CXCR4, and SOX10 mRNAs	[138]
Anti-PD1	FTO	Oncogene	High	CRC	PD-L1	Promotes expression of PD-L1	[139]
Anti-PD1	ALKBH5	Oncogene	NA	Melanoma	MCT4	Promotes expression of MCT4	[140]