Table 2.

Comparison of substrate changes between non-human-primates and humans. Protein ratio of BACE inhibition versus placebo/vehicle of sSEZ6, sIL6ST/sgp130, and sAPPβ detected by mass spectrometry (MS), Western Blotting (WB) or immunoassay ± standard deviation in %

Species	Macaca mulatta			Homo sapiens
Inhibitor	100 mpk MBI-4		3 mpk Verubecestat	100 mg Verubecestat
Method	MSa	WB/immunoassay	MSa	WB/immunoassay
sSEZ6	35.9 ± 1.38%	14.0 ± 4.8%b	38.7 ± 7.7%	25.3 ± 14.2%d
sIL6ST/sgp130	46.1 ± 6.7%	21.8 ± 2.0%b	60.1 ± 8.6%	40.2 ± 8.5%e
sAPPβ	–	7.1 ± 7.4%b / 18.4 ± 4.8%c	–	21.7 ± 4.7%f

^amass spec data are taken from Fig. 1

^bWestern Blotting data are taken from Fig. 1

^cimmunoassay data for sAPPβ are taken from [27] for non-human primates

^dWestern Blotting data are taken from Fig. 2

^eELISA data are taken from Fig. 2

^fimmunoassay data for sAPPβ are taken from [28] for humans