TABLE 4.
Drug classes and combinations used in treating patients with bipolar disorder, expressed as n (%).
| Acute episode | Maintenance period | ||||||
| Combinations by class | Baseline (n = 204) | 3 months (n = 173) | 6 months (n = 153) | 9 months (n = 147) | 12 months (n = 149) | χ2 | P |
| MS | 3 (1.5) | 8 (4.6) | 10 (6.5) | 14 (9.5) | 15 (10.1) | 15.552 | 0.004 |
| MS + AP | 90 (44.1) | 62 (35.8) | 60 (39.2) | 55 (37.4) | 53 (35.6) | 3.864 | 0.426 |
| MS + AD | 2 (1.0) | 8 (4.6) | 4 (2.6) | 5 (3.4) | 1 (0.7) | 7.580 | 0.091 |
| MS + BZD | 0 (0) | 2 (1.2) | 2 (1.3) | 2 (1.4) | 3 (2.0) | 4.299 | 0.322 |
| MS + AP + AD | 28 (13.7) | 18 (10.4) | 15 (9.8) | 18 (12.2) | 18 (12.1) | 1.680 | 0.797 |
| MS + AP + BZD | 29 (14.2) | 12 (6.9) | 9 (5.9) | 7 (4.8) | 8 (5.4) | 15.616 | 0.003 |
| MS + AD + BZD | 5 (2.5) | 1 (0.6) | 3 (2.0) | 0 (0) | 3 (2.0) | 5.144 | 0.233 |
| MS + AP + AD + BZD | 26 (12.7) | 13 (7.5) | 8 (5.2) | 5 (3.4) | 8 (5.4) | 14.105 | 0.007 |
| AP | 4 (2.0) | 16 (9.2) | 10 (6.5) | 10 (6.8) | 14 (9.4) | 13.066 | 0.010 |
| AP + AD | 6 (2.9) | 14 (19.2) | 14 (9.2) | 9 (6.1) | 7 (4.7) | 7.802 | 0.099 |
| AP + BZD | 0 (0) | 3 (1.7) | 3 (2.0) | 5 (3.4) | 3 (2.0) | 7.255 | 0.087 |
| AP + AD + BZD | 10 (4.9) | 5 (2.9) | 3 (2.0) | 4 (2.7) | 6 (4.0) | 2.692 | 0.619 |
| AD | 1 (0.5) | 5 (2.9) | 6 (3.9) | 6 (4.1) | 4 (2.7) | 6.902 | 0.126 |
| AD + BZD | 0 (0) | 5 (2.9) | 5 (3.3) | 5 (3.4) | 3 (2.0) | 8.865 | 0.046 |
| BZD | 0 (0) | 1 (0.6) | 1 (0.7) | 2 (1.4) | 3 (2.0) | 4.588 | 0.225 |
AD, antidepressant; AP, antipsychotic; MS, mood stabilizer; BZD, benzodiazepine.