FIGURE 5.

Contributions of $\nu$, ${\chi }_H$, ${\chi }_{\mathit{TS}}$, and $\epsilon$ with and without chemical interactions at 298 K. Contributions for PEG8000 to $\mathrm{\Delta \Delta }{G}_U^{\circ \prime }$ (a) and $T\mathrm{\Delta \Delta }{S}_U^{\circ \prime }$ versus $\mathrm{\Delta \Delta }{H}_U^{\circ \prime }$(b), for $\epsilon =0$. Relative contributions, $f$, of ${\chi }_H$ and $\nu +{\chi }_{\mathit{TS}}$ to the total free energy compared to buffer for different PEG sizes and concentrations (c). The gray line represents $f_{{\chi }_H}+f_{\nu +{\chi }_{\mathit{TS}}}=1$. Low $\mathrm{\Delta \Delta }{H}_U^{\circ \prime }$ and $T\mathrm{\Delta \Delta }{S}_U^{\circ \prime }$ regime of the entropy–enthalpy plot from panel b for $\epsilon =0$ (d), and $\epsilon =-0.08$ (e).