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. 2023 Feb 7;15:1019173. doi: 10.3389/fnmol.2022.1019173

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Copyright © 2023 Lee, Song, Hwang, Baek, Baek, Kim, Park, Choi, Pyo and Cho.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Very early and delayed exposure to EE decreases TUNEL immunopositivity in the cerebral cortex and the hippocampus. Representative TUNEL images from the very early exposure EE group and its control group are shown in (A), and the corresponding quantification is shown in (B) (n = 8 per group). Representative TUNEL images from the delayed exposure group and its control group are shown in (C), and the corresponding quantification is shown in (D) (n = 4 per group). All statistical comparisons were performed via Student’s t-tests. Data represented are means ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001. EE, environmental enrichment; TUNEL, terminal deoxynucleotidyl transferase dUTP nick-end labeling.