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. 2023 Feb 2;8(1):e00558-22. doi: 10.1128/msphere.00558-22

FIG 8.

FIG 8

Mouse Ace2 (mAce2) expression, but not hACE2, is downregulated in the lung of SARS-CoV-2-infected K18-hACE2, C57BL/6J, and BABL/c mice. The relative expression of mAce2 (A), hACE2 (B), and mTmprss2 (C) was evaluated in the lung of K18-hACE2 mice at 2, 4, and 6 dpi following infection with SARS-CoV-2 MA10 and USA-WA1/2020 strains. The relative expression of mAce2 (D and F) and mTmprss2 (E and G) expression were evaluated at 2, 4, and 7 dpi in the lung of mock and MA10-infected C57BL/6J and BALB/c mice, respectively. Bars represent the mean ± standard deviation. *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001.