Table 6.
ROC Curve to Assess Diagnostic Value of Biomarkers in Patients with SARS-CoV-2
| Variables | AUC | 95% CI | p-value | Cut-Off | Sensitivity | 95% CI | Specificity | 95% CI | PPV | 95% CI | NPV | 95% CI |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CRP | 0.903 | 0.822 to 0.955 | <0.0001 | >0.95 | 83.33 | 71.5–91.7 | 83.33 | 65.3–94.4 | 90.9 | 81.7–95.7 | 71.4 | 58.1–81.8 |
| MDA | 0.517 | 0.409 to 0.623 | 0.7865 | >16.51 | 60.00 | 46.5–72.4 | 3.33 | 0.08–17.2 | 55.4 | 50.0–60.7 | 4.0 | 0.6–22.7 |
| NO | 0.807 | 0.710 to 0.882 | <0.0001 | >39.01 | 70.00 | 56.8–81.2 | 86.67 | 69.3–96.2 | 91.3 | 80.6–96.4 | 59.1 | 48.9–68.5 |
| Zinc | 0.795 | 0.697 to 0.873 | <0.0001 | ≤78.35 | 91.67 | 81.6–97.2 | 63.33 | 43.9–80.1 | 83.3 | 75.6–89.0 | 79.2 | 61.1–90.2 |
| Copper | 0.827 | 0.733 to 0.899 | <0.0001 | >11.93 | 66.67 | 53.3–78.3 | 96.67 | 82.8–99.9 | 97.6 | 85.2–99.6 | 59.2 | 50.2–67.6 |
| Vitamin C | 0.528 | 0.420 to 0.634 | 0.670 | >32.56 | 61.67 | 48.2–73.9 | 60.00 | 40.6–77.3 | 75.5 | 65.6–83.3 | 43.9 | 33.6–54.7 |
| TAC | 0.687 | 0.581 to 0.781 | 0.003 | ≤0.065 | 81.67 | 69.6–90.5 | 53.33 | 34.3–71.7 | 77.8 | 70.1–83.9 | 55.3 | 43.6–73.2 |
| SOD | 0.740 | 0.637 to 0.827 | 0.0002 | ≤0.85 | 86.67 | 75.4–94.1 | 76.67 | 57.7–90.1 | 88.1 | 79.4–93.5 | 74.2 | 59.4–85.0 |
| GPx | 0.579 | 0.470 to 0.682 | 0.2100 | >18.07 | 61.67 | 48.2–73.9 | 56.67 | 37.4–74.5 | 74.0 | 64.4–81.8 | 42.5 | 32.1–53.6 |
| Catalase | 0.570 | 0.461 to 0.674 | 0.2700 | ≤1.29 | 51.67 | 38.4–64.8 | 66.67 | 47.2–82.7 | 75.6 | 63.9–84.5 | 40.8 | 32.4–49.8 |
Notes: The ROC curve analysis was performed by MedCalc 20. A p-value of less than 0.05 was considered statistically significant.
Abbreviations: AUC, area under curve; CI, confidence interval; CRP, C-reactive protein; GPx, glutathione peroxidase; MDA, malondialdehyde; NO, nitric oxide; NPV, negative predictive value; PPV, positive predictive value; SOD, superoxide dismutase; TAC, total antioxidant capacity.