TABLE 1.
Demographics.
| EVE (n = 91) | CNI (n = 91) | p-value | |
|---|---|---|---|
| Characteristic | |||
| Age (yr), mean | 51.64 ± 13.87 | 50.81 ± 13.87 | 0.16 |
| Gender: male, n (%) | 49 (53.8) | 49 (53.8) | 1.00 |
| Body mass index (mean ± SD) | 25.00 ± 4.45 | 25.93 ± 5.28 | 0.15 |
| Indication for transplantation, n (%) | |||
| Chronic obstructive pulmonary disease | 43 (47.2) | 43 (47.2) | 1.00 |
| Cystic fibrosis | 19 (20.9) | 19 (20.9) | 1.00 |
| Interstitial lung disease | 19 (20.9) | 19 (20.9) | 1.00 |
| Pulmonary hypertension | 6 (6.6) | 6 (6.6) | 1.00 |
| Other | 4 (4.4) | 4 (4.4) | 1.00 |
| Transplantation type, n (%) | |||
| Bilateral sequential lung | 81 (89.0) | 81 (89.0) | 1.00 |
| Single lung | 9 (9.9) | 9 (9.9) | 1.00 |
| Heart and lung | 1 (1.1) | 1 (1.1) | 1.00 |
| Maintenance Immunosuppression, n (%) a | |||
| Tacrolimus | 75 (82.4) | 82 (90.1) | 0.07 |
| Ciclosporin | 16 (17.6) | 9 (9.9) | 0.07 |
| Mycophenolate | 38 (41.7) | 33 (36.3) | 0.44 |
| Azathioprine | 34 (37.4) | 52 (57.1) | 0.009 |
| No antimetabolite | 19 (20.9) | 6 (6.6) | 0.014 |
| Rejection | |||
| Acute Rejection b | 13 (14.3) | 15 (16.5) | 0.66 |
| Diagnosis of CLAD c | 57 (62.6) | 52 (57.1) | 0.41 |
| RAS | 27 (29.7) | 19 (20.9) | 0.16 |
| BOS | 30 (33.0) | 33 (36.3) | 0.60 |
Abbreviations: ACR, acute cellular rejection; BOS, bronchiolitis obliterans syndrome; CLAD, chronic lung allograft dysfunction; EVE, everolimus; ISHLT, international society for heart and lung transplantation; RAS, restrictive allograft syndrome.
a
Maintenance immunosuppression at time of starting on EVE.
b
Episode of ISHLT graded ≥2 ACR pre or post starting on EVE.
c
Diagnosis of CLAD pre or post starting on EVE.