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. 2023 Feb 7;10:1121964. doi: 10.3389/fmolb.2023.1121964

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Copyright © 2023 Khan, Khan, Khan, Ud Din, Khan, Khan and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of LGMN functional mechanism in the tumor microenvironment. It was found that the TGF-3/FAK pathway targets lipid metabolism to overcome the treatment resistance related to EMT. LGMN activation is exploited to induce TAM repolarization. Whereas cellular proliferation, invasion, and metastasis are all regulated by the PI3K/AKT pathway. Finally, lowering TAM levels in the tumor stroma can drastically modify the tumor microenvironment, hence limiting tumor development and spreading.