Table 1.
Coding SNPs are present in Pfs230 D1+ amino acids 552–731
| Residue | Coding SNP | Allele frequency (%) | RUPA-32 | RUPA-55 | RUPA-97 | 4F12 | RUPA-38 | 15C5 | LMIV 230-01 | LMIV 230-02 |
|---|---|---|---|---|---|---|---|---|---|---|
| 561 | D561N | 0.014 | – | – | – | – | ▀ | – | – | – |
| 574 | V574I | 0.014 | – | – | – | – | – | – | ▀ | – |
| 575 | S575P | 0.014 | – | – | – | – | – | – | ▀ | – |
| 583 | A583T | 0.022 | ▀ | ▀ | ▀ | ▀ | – | – | – | – |
| 602 | T602K | 0.014 | ▀ | ▀ | ▀ | ▀ | – | – | – | – |
| 605 | G605S | 94.4 | – | – | – | – | – | – | – | – |
| 612 | E612K | 0.0072 | ▀ | ▀ | ▀ | – | – | – | ▀ | – |
| 632 | V632A | 0.029 | ▀ | ▀ | ▀ | – | – | – | – | – |
| 637 | D637N | 0.014 | – | – | – | – | – | – | – | – |
| 644 | K644Q | 0.014 | – | – | – | – | ▀ | – | – | – |
| 652 | T652R | 2.1 | – | – | – | – | – | – | – | – |
| 654 | E654K | 0.014 | – | – | – | – | – | – | – | – |
| 655 | E655V | 0.35 | – | – | – | – | – | – | ▀ | – |
| 656 | T656N | 0.61 | – | – | – | – | – | – | ▀ | – |
| 661 | K661N | 21.6 | – | – | – | – | – | – | – | – |
| K661T | 0.029 | – | – | – | – | – | – | – | – | |
| 665 | K665Q | 0.0072 | – | – | – | – | – | ▀ | – | – |
| 675 | T675K | 0.0072 | – | – | – | – | – | – | – | ▀ |
| 687 | V687I | 0.036 | – | – | – | – | – | – | – | – |
| 697 | H697Q | 0.014 | – | – | – | – | – | ▀ | – | – |
| 699 | A699T | 0.33 | – | – | – | – | – | ▀ | – | |
| 701 | V701M | 0.0072 | – | – | – | – | – | ▀ | – | |
| 713 | D713Y | 2.9 | – | – | – | – | – | – | – | – |
| 714 | D714G | 0.029 | – | – | – | – | – | – | – | – |
| D714N | 0.014 | – | – | – | – | – | – | – | – | |
| 715 | N715K | 0.022 | – | – | – | – | – | – | – | – |
| 716 | K716N | 0.022 | ▀ | ▀ | ▀ | – | – | – | – | – |
| 719 | N719S | 0.022 | ▀ | ▀ | ▀ | – | – | – | – | – |
| 726 | Y726H | 0.0072 | – | – | – | – | – | – | ▀ | – |
| 727 | V727I | 0.014 | – | – | – | – | – | – | – | – |
Coding SNPs occurring within the epitopes reported for all known antibody-antigen structures are indicated with black squares. PDB IDs for Fab 4F12 and scFv LMIV230-01 are 6OHG and 7JUM, respectively.