Figure 5.

Diet-induced obesity (DIO) affects house dust mite (HDM)-induced allergic airway inflammation and remodeling. Low-fat diet (LFD)- or high-fat diet (HFD)-fed mice were subjected to HDM sensitization and challenge to induce allergic airway inflammation. Bronchoalveolar lavage (BAL) fluids were analyzed for total cell counts (A), IL-33 (B), IL-5 (C), and IL-13 (D). Lung tissues were harvested for analysis of mRNA levels of Clca1 (E), Muc5ac (F), Col1a1 (G), and Col3a1 (H). *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; 2-way ANOVA; n = 4–8 from two independent experiments.