Fig. 2.

fmARKO mice showed lower muscle strength and endurance capacity. (A) The results of grip test [forelimb maximal grip strength normalized for body weight (g/g)], wire hang test [holding impulse (Ns)], and treadmill test [total work output (J)] in 13-wk-old, 12- to 13-mo-old, and 2-y-old control mice (n = 3 to 8/group). (B–D) The results of grip test, wire hang test, and treadmill test were compared between control and fmARKO mice at (B) 13-wk-old, (C) 12- to 13-mo-old, and (D) 2-y-old (n = 3 to 8/group). (E) In situ GAST muscle tetanic contraction during sciatic nerve stimulation and the maximal muscle contraction force (n = 3 to 7/group). Error bars indicate SEM; *P < 0.05, **P < 0.01, ***P < 0.001.