Table 3.

Univariate analyses and multivariate analyses.

Variable	Univariate analyses		Multivariate analyses
	Progression-Free Survival HR (95%CI)	Overall Survival HR (95%CI)	Progression-Free Survival HR (95%CI)	Overall Survival HR (95%CI)
Performance status
0-1 versus 2	0.60 (0.41-0.88)	0.38 (0.29-0.51)	0.85 (0.51-1.40)	0.49 (0.28-0.87)
Gender
Male versus Female	1.00 (0.90-1.11)	1.02 (0.90-1.17)	1.11 (0.95-1.30)	1.13 (0.86-1.47)
Brain metastases
Yes versus No	1.24 (1.07-1.43)	1.25 (1.06-1.48)	0.98 (0.76-1.27)	1.01 (0.75-1.35)
Age
<70 versus ≥70	0.96 (0.86-1.07)	0.89 (0.78-1.00)	—	—
<65 versus ≥65	1.49 (0.66-3.38)	1.23 (0.43-3.48)	1.13 (0.93-1.37)	1.13 (0.91-1.41)
Smoking status
Current/Former smoker versus No-smoker	0.82 (0.48-1.38)	0.96 (0.61-1.50)	1.05 (0.67-1.65)	1.32 (1.08-1.63)
Histology
Non-squamous versus Squamous	0.98 (0.87-1.10)	0.98 (0.85-1.15)	—	0.94 (0.60-1.46)
Baseline steroids
No/<10mg versus ≥10mg	0.46 (0.26-0.80)	0.29 (0.06-1.29)	0.80 (0.52-1.24)	0.60 (0.40-0.90)
IRAE
Yes versus No	0.76 (0.47-1.24)	0.71 (0.30-1.69)	—	—
PD-L1 expression
<90% versus ≥90%	0.94 (0.69-1.29)	1.13 (0.76-1.68)	—	—
Previous radiotherapy
Yes versus No	0.89 (0.48-1.65)	0.97 (0.64-1.48)	—	0.93 (0.57-1.53)