Table 5.

Meta-analysis of the rate of SAEs, pneumonitis, and drug-related death in combination therapy.

Studies	Items for evaluation	Rate (%)	95%CI
Pembro + Chemo in RCT studies	Grade 3-5 TRAEs	64	49-78%
	Grade 3-5 IRAEs	10	6-14%
	Pneumonitis (≥Grade 3)	4	2-6%
	Drug-related death	2	1-4%
Pembro in RCT studies	Grade 3-5 TRAEs	20	15-26%
	Grade 3-5 IRAEs	9	6-12%
	Pneumonitis (≥Grade 3)	3	2-4%
	Drug-related death	2	0-3%
Pembro + Chemo in Retrospective studies	Grade 3-5 TRAEs	51	40-61%
	Pneumonitis (≥Grade 3)	2	-2-6%
	Drug-related death	2	-2-6%
Pembro in Retrospective studies	Grade 3-5 IRAEs	17	14-21%
	Pneumonitis (≥Grade 3)	3	1-5%
	Drug-related death	4	-2-10%