Scheme 2.
(a) Hydrazine, Ethanol, 120 °C microwave, 120 °C (b) NaH (60%), Ethyl bromoacetate, DMF, 0 °C to rt, 1h; (c) LiOH, MeOH, THF, H2O, rt 3h (d) N-Me aniline, T3P, DIPEA, THF, 70 °C, 1h.
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