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. Author manuscript; available in PMC: 2023 Oct 13.
Published in final edited form as: J Med Chem. 2022 Sep 20;65(19):13198–13215. doi: 10.1021/acs.jmedchem.2c00998

Scheme 6.

Scheme 6.

(a) NaH, 30 min rt, DMF; (b) propargyl bromide, 2h rt; (c) 2-[2,4-bis(trifluoromethyl)phenyl]acetic acid, T3P, DIPEA, THF rt, 1h; (d) Aryl bromide, Pd(PPh3)4, CuI, TEA, DMF, 70 °C, 4h.