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. Author manuscript; available in PMC: 2023 Oct 13.
Published in final edited form as: J Med Chem. 2022 Sep 20;65(19):13198–13215. doi: 10.1021/acs.jmedchem.2c00998

Scheme 7.

Scheme 7.

(a) 2-[2,4-bis(trifluoromethyl)phenyl]acetic acid, 4-anilinobut-2-yn-1-ol, T3P, DIPEA, THF rt, 1h; (b) 4-methylbenzenesulfonyl chloride, N,N-diethylethanamine N,N-dimethylpyridin-4-amine, DCM, 0 °C; (c) sodium azide, DMF, rt; (d) Ph3P, THF, rt (e) carboxylic acid, DIPEA, HATU or T3P, DMF or THF rt.