Table 2. Dose-limiting toxicity (DLT) according to SMM status.
Total (n = 97) | Without low SMM (n = 55) | Low SMM (n = 42) | P-value |
---|---|---|---|
DLT | <0.01 | ||
No | 49 (89.1%) | 27 (64.3%) | |
Yes | 6 (10.9%) | 15 (35.7%) | |
DLT in cisplatin | |||
No | 38 (90.5%) | 20 (66.7%) | 0.01 |
Yes | 4 (9.5%) | 10 (33.3%) | |
DLT in paclitaxel/carboplatin | 0.14 | ||
No | 11 (84.6%) | 7 (58.3%) | |
Yes | 2 (15.4%) | 5 (41.7%) | |
Reason of DLT | 0.45 | ||
Haematopoietic toxicity | 6 (100%) | 10 (66.7%) | |
Nephrotoxicity | 0 | 2 (13.3%) | |
Infection | 0 | 3 (20%) |
DLT dose limiting toxicity; SMM skeletal muscle mass; Significance p calculated by Pearson’s chi-squared test