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. 2023 Feb 21;18(2):e0282015. doi: 10.1371/journal.pone.0282015

Table 2. Dose-limiting toxicity (DLT) according to SMM status.

Total (n = 97) Without low SMM (n = 55) Low SMM (n = 42) P-value
DLT <0.01
    No 49 (89.1%) 27 (64.3%)
    Yes 6 (10.9%) 15 (35.7%)
DLT in cisplatin
    No 38 (90.5%) 20 (66.7%) 0.01
    Yes 4 (9.5%) 10 (33.3%)
DLT in paclitaxel/carboplatin 0.14
    No 11 (84.6%) 7 (58.3%)
    Yes 2 (15.4%) 5 (41.7%)
Reason of DLT 0.45
    Haematopoietic toxicity 6 (100%) 10 (66.7%)
    Nephrotoxicity 0 2 (13.3%)
    Infection 0 3 (20%)

DLT dose limiting toxicity; SMM skeletal muscle mass; Significance p calculated by Pearson’s chi-squared test