Table 1.
Independent and dependent variables used to optimize RPG niosomes formulations by 2FI I-Optimal statistical design.
Factors (independent variables) | Levels | ||
---|---|---|---|
Low (−1) | Medium (0) | High (+1) | |
X1: Cholesterol % | 1 | – | 2 |
X2: Span 60 % | 1 | 3 | 5 |
X3: PeceolTM % | 1 | – | 2 |
Dependent variables | Goals | ||
Y1: Particle size (nm) | Minimize | ||
Y2: Zeta potential (mV) | Maximize | ||
Y3: Polydispersity index | Minimize | ||
Y4: Entrapment efficiency (%) | Maximize |