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. 2023 Feb 20;30(1):2181747. doi: 10.1080/10717544.2023.2181747

Table 1.

Independent and dependent variables used to optimize RPG niosomes formulations by 2FI I-Optimal statistical design.

Factors (independent variables) Levels    
Low (−1) Medium (0) High (+1)
X1: Cholesterol % 1 2
X2: Span 60 % 1 3 5
X3: PeceolTM % 1 2
Dependent variables Goals    
Y1: Particle size (nm) Minimize    
Y2: Zeta potential (mV) Maximize    
Y3: Polydispersity index Minimize    
Y4: Entrapment efficiency (%) Maximize