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. 2023 Feb 6;51(3):25. doi: 10.3892/ijmm.2023.5228

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Copyright: © Dong et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Single-cell level discrimination of cell sources in X-SCID patient BMMNCs. (A) Strategy to discriminate autologous and maternal cells in this X-SCID patient BMMNCs. (B) UMAP plot of BMMNCs in the X-SCID patient with cells color-coded from different cell sources. The T and NK-like lymphocytes were highlighted in the red irregular pattern. (C) The cell number and composition of cell sources in each cluster in the X-SCID patient's BMMNCs. Top, the cell number in each cluster; bottom, the percentage of cells from each cell source in each cluster, colors represent cell sources. X-SCID, X-linked severe combined immunodeficiency; BMMNCs, bone marrow mononuclear cells; UMAP, uniform manifold approximation and projection.