Table 3.
Association between LAMA1 single-nucleotide polymorphism and esophageal squamous cell carcinoma while controlling age and gender
| Locus | Genotype | ESCC case | Control | Codominant model | Dominant model | Recessive model | Additive model | Multiplicative model | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Or (95%CI) | pvalue | Or (95% CI) | pvalue | Or (95% CI) | pvalue | Or (95% CI) | pvalue | Or (95% CI) | pvalue | ||||
| rs62081531 | G/G | 729 (69.9) | 765 (66.9) | Ref | 0.830 (0.691–0.997) | 0.046 | 0.968 (0.606–1.545) | 0.891 | 0.870 (0.743–1.017) | 0.081 | 0.866 (0.739–1.015) | 0.076 | |
| G/A | 261 (25.0) | 334 (29.2) | 0.820 (0.677–0.993) | 0.042 | |||||||||
| A/A | 34 (3.3) | 39 (3.4) | 0.915 (0.571–1.465) | 0.711 | |||||||||
|
| |||||||||||||
| rs621993 | G/G | 704 (67.5) | 777 (68.0) | Ref | 0.981 (0.818–1.177) | 0.839 | 1.114 (0.682–1.818) | 0.666 | 0.997 (0.852–1.167) | 0.970 | 0.997 (0.851–1.167) | 0.970 | |
| G/A | 288 (27.6) | 328 (28.7) | 0.969 (0.803–1.17) | 0.744 | |||||||||
| A/A | 33 (3.2) | 33 (2.9) | 1.104 (0.674–1.807) | 0.695 | |||||||||
|
| |||||||||||||
| rs539713 | A/A | 525 (50.3) | 595 (52.1) | Ref | 1.044 (0.881–1.236) | 0.621 | 0.805 (0.576–1.124) | 0.202 | 0.991 (0.866–1.135) | 0.900 | 0.992 (0.868–1.133) | 0.902 | |
| G/A | 436 (41.8) | 456 (39.9) | 1.084 (0.909–1.292) | 0.371 | |||||||||
| G/G | 64 (6.1) | 87 (7.6) | 0.834 (0.591–1.175) | 0.299 | |||||||||
|
| |||||||||||||
| rs566655 | T/T | 738 (70.8) | 832 (72.8) | Ref | 1.057 (0.875–1.277) | 0.563 | 1.340 (0.736–2.441) | 0.338 | 1.071 (0.904–1.268) | 0.430 | 1.070 (0.904–1.266) | 0.432 | |
| T/G | 263 (25.2) | 286 (25.0) | 1.037 (0.853–1.259) | 0.717 | |||||||||
| G/G | 24 (2.3) | 20 (1.7) | 1.353 (0.741–2.469) | 0.325 | |||||||||
|
| |||||||||||||
| rs73938538 | A/A | 829 (79.5) | 891 (78.0) | Ref | 0.844 (0.684–1.042) | 0.115 | 0.854 (0.373–1.957) | 0.710 | 0.857 (0.706–1.042) | 0.122 | 0.859 (0.707–1.042) | 0.124 | |
| C/A | 184 (17.6) | 234 (20.5) | 0.845 (0.682–1.048) | 0.125 | |||||||||
| C/C | 10 (1.0) | 13 (1.1) | 0.827 (0.361–1.896) | 0.653 | |||||||||
|
| |||||||||||||
| rs607230 | T/T | 49 (4.7) | 37 (3.2) | Ref | 0.657 (0.425–1.016) | 0.059 | 1.046 (0.875–1.25) | 0.624 | 0.981 (0.844–1.140) | 0.803 | 0.981 (0.842–1.142) | 0.801 | |
| T/C | 293 (28.1) | 361 (31.6) | 0.613 (0.389–0.965) | 0.034 | |||||||||
| C/C | 664 (63.7) | 739 (64.7) | 0.678 (0.437–1.053) | 0.084 | |||||||||
OR: odds ratio; CI: confidence interval.