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. 2023 Jan 30;51(3):1173–1188. doi: 10.1093/nar/gkad015

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — CryoEM structures reveal mobility of MBD2 in V63E. CryoEM density maps and model for MutSα WT and MSH2 V63E. (A) CryoEM map of MutSα WT colored as in Figure 3A. (B) Atomic model of MutSα, colored as in Figure 3A. (C) Map (left) and model (right) of MBD interface with MBD2 in dark purple and MBD6 in light purple for better visibility. (D) The subclasses of the MSH2 V63E dataset show flexibility of the MBD2 domain. Left panel: closed MBD2 reminiscent of MutSα WT; middle panel: disordered MBD2; right panel: disordered MBD2 and dragged-out connector domain.