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. Author manuscript; available in PMC: 2023 Feb 21.
Published in final edited form as: Annu Rev Med. 2022 Jul 29;74:261–277. doi: 10.1146/annurev-med-043021-032816

Figure 1.

Figure 1

Hepcidin has a homeostatic role in conditions associated with physiological hepcidin stimulation (a) or suppression (b) and a pathological role in iron-restrictive disorders (c) and iron-overload disorders (d). Iron flows are shown in shades of blue indicative of intensity. Hepcidin and its effects are shown in red; normal and pathological hepcidin modulators are shown in gold. Abbreviations: Fe-Tf, iron-transferrin; MT-2, matriptase-2; RBC, red blood cell. Figure adapted from Reference 5 with permission.