Figure 2.

The predictive ability (R²) of a PGS model based on UKBB or BBJ discovery dataset, compared to the joint model of both UKBB and BBJ when predicting 28,880 European individuals

(A) The main bars represent R² values and error bars correspond 95% confidence intervals. Two sets of GWAS summary statistics were obtained from UKBB and BBJ discovery GWAS datasets to estimate two sets of PGSs, i.e., UKBB and BBJ PGSs. In addition, a joint model fitting both UKBB and BBJ PGSs was compared.

(B) Dot points represent the differences of R² values between the joint model and UKBB or BBJ PGS model, and error bars indicate 95% confidence intervals of the difference.