Table 2.
Six conditionally distinct proinsulin signals
|
Marginal associations |
Conditional associations |
LD with primary (r2) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Locus | rs ID | EA/NEA | EAF | Beta | Std Err | p value | bC | bC_se | pC | |
| STARD10 | rs481206 | C/T | 0.69 | 0.12 | 0.01 | 3.8 × 10−62 | 0.06 | 0.01 | 1.0 × 10−16 | 0.068 |
| MADD | rs35233100 | C/T | 0.94 | 0.35 | 0.02 | 1.9 × 10−104 | 0.23 | 0.02 | 3.0 × 10−46 | 0.154 |
| MADD | rs1449626 | A/C | 0.78 | 0.01 | 0.01 | 4.8 × 10−1 | 0.06 | 0.01 | 7.0 × 10−15 | 0.068 |
| PCSK1 | rs2117141 | C/T | 0.41 | 0.06 | 0.01 | 4.0 × 10−16 | 0.07 | 0.01 | 1.9 × 10−24 | 0.008 |
| SGSM2 | rs2447103 | C/A | 0.51 | 0.07 | 0.01 | 3.5 × 10−26 | 0.07 | 0.01 | 5.3 × 10−22 | 0.004 |
| DDX31 | rs7864386 | G/A | 0.56 | 0.03 | 0.01 | 1.6 × 10−6 | 0.04 | 0.01 | 1.8 × 10−10 | 0.027 |
Conditionally distinct signals identified with GCTA-COJO and the eMERGE reference panel. EA, effect allele; NEA, non-effect allele; EAF, effect allele frequency; Std Err, SE of beta; bC, conditional beta; bC_se, conditional SE of beta; pC, conditional p value. Results for both MADD signals are from the analyses conditioning on the other two MADD signals.