20. Estimated glomerular filtration rate (eGFR) ‐ Studies undertaking multivariable regression analyses to determine the effect of eGFR on progression to PDR.
| Study | Study type | Time years | N at baseline | Adjustment factors | Effect estimate | P value | Comments | ||
| Type | Value | 95% CI | |||||||
| Type 2 diabetes | |||||||||
| Cho 2019 | Retrospective cohort | 4 | 405 | HbA1c, age | HR | 2.55 | 1.22 to 5.35 | < 0.05 | a reduction in eGFR of > 20% |
| Hsieh 2018 | Prospective cohort | 8 | 2096 | DM duration, age, sex, SBP, BMI, serum fasting glucose, cholesterol, low‐ and high‐density lipoprotein, triglycerides | HR | 1.55a 2.05b 4.22c |
0.63 to 3.82 0.72 to 5.86 1.27 to 14.07 |
0.34 0.18 0.02 |
|
BMI: body mass index; CI: confidence interval; DBP: diastolic blood pressure; DM: diabetes mellitus; DR: diabetic retinopathy; HbA1c: glycated haemoglobin/haemoglobin A1c; HR: hazard ratio; NPDR: non‐proliferative diabetic retinopathy; OR: odds ratio; PDR: proliferative diabetic retinopathy; RR: risk ratio; SBP: systolic blood pressure; vs: versus
a46‐60mL/min/1.73m2 b30‐45mL/min/1.73m2 c<30 mL/min/1.73m2