25. Intra‐ocular pressure ‐ Studies undertaking multivariable regression analyses to determine the effect of intra‐ocular pressure at baseline on progression to PDR.

Study	Study type	Time years	N at baseline	Adjustment factors	Effect estimate			P value	Comments
					Type	Value	95% CI
Type 1 diabetes
WESDR  Moss 1993	Prospective cohort	4	996	HbA1c, DR severity, and age at baseline.	OR	1.04	0.96 to 1.13
Type 2 diabetes
WESDR Moss 1993	Prospective cohort	4	674	HbA1c, duration of DM, and DR severity at baseline	OR	0.95	0.83 to 1.08

BMI: body mass index; CI: confidence interval; DBP: diastolic blood pressure; DM: diabetes mellitus; DR: diabetic retinopathy; HbA1c: glycated haemoglobin/haemoglobin A1c; HR: hazard ratio; NPDR: non‐proliferative diabetic retinopathy; OR: odds ratio; PDR: proliferative diabetic retinopathy; RR: risk ratio; SBP: systolic blood pressure; vs: versus