Silva 2015.

Study characteristics
Methods	Study design: prospective cohort longitudinal Location: USA Time period: not reported Outcome: PDR and HRC‐PDR Outcome measurement: incidence
Participants	Number of participants: 100 Diabetes type: T1D and T2D Inclusion criteria: age 18 years or older, diagnosis of T1D or T2D as defined by the American Diabetes Association; willingness to comply with the study imaging procedures, and willingness to sign the institutionally approved informed consent form for the study Exclusion criteria: no history of diabetes; history of a condition in either eye that might preclude pupil dilation, or using eye drops (mydriatic or miotic) that would alter pupil size or reactivity
Notes	Link to data extraction table, risk of bias assessment, and results: osf.io/ngjbx/?view_only=bfc4ccc7f0f547c3813e51fdb59c209c
Item	Authors' judgement	Support for judgement
Study participation	Unclear	See ‘Notes’ above for link to risk of bias assessment
Study attrition	No	See ‘Notes’ above for link to risk of bias assessment
Prognostic factor measurement	Unclear	See ‘Notes’ above for link to risk of bias assessment
Outcome measurement	Yes	See ‘Notes’ above for link to risk of bias assessment
Adjustment for other prognostic factors	Unclear	See ‘Notes’ above for link to risk of bias assessment
Statistical analysis and reporting	Yes	See ‘Notes’ above for link to risk of bias assessment