Table 1.
Study participants*.
| PTSD-CC | PTSD-NU | MDD-CC | MDD-NU | CC | NU | |
|---|---|---|---|---|---|---|
| Demographics | N = 16 | N = 17 | N = 20 | N = 19 | N = 38 | N = 23 |
| Sex (M:F) (% F) | 7:9 (56%) | 14:3 (18%) | 5:15 (75%) | 10:9 (47%) | 16:22 (58%) | 16:7 (30%) |
| Age (years) | 37.5 (11.7) | 38.4 (11.5) | 34.8 (13.6) | 39.5 (12.0) | 33.7 (11.9) | 41.9 (12.9) |
| Weight (kg) | 84.78 (21.33) | 79.50 (9.79) | 79.04 (16.03) | 74.61 (19.1) | 76.32 (15.4) | 81.35 (13.1) |
| Medicated (# medicated) | 4 | 7 | 3 | 6 | 0 | 0 |
| Injected dose of FPEB (MBq)** | 170.94 (99.53) | 158.73 (95.09) | 171.68 (212.01) | 146.89 (149.85) | 159.84 (128.39) | 155.77 (111.74) |
| Injected mass of FPEB (µg/kg)** | .0046 (.009) | 0.004 (.010) | .007 (.027) | 0.004 (.010) | .005 (.012) | 0.005 (.011) |
| Mood/ depressive symptoms | - | |||||
| MADRS | 18.9 (8.9) | 20.2 (7.3) | 22.1 (5.4) | 22.2 (8.2) | 0.4 (0.9) | 0.7 (1.4) |
| BDI | 23.3 (12.4) | 23.6 (6.6) | 27.1 (10.7) | 25.2 (9.9) | 0.9 (1.9) | 1.4 (1.6) |
| Nicotine use characteristics | ||||||
| Dependence (FTND) | — | 5.2 (2.9) | — | 6.3 (3.2) | — | 4.4 (2.7) |
| Craving (QSU brief total score) | — | 44.4 (16.5) | — | 31.6 (19.4) | — | 23.2 (12.8) |
| Smoking (n) | — | 16 | — | 18 | — | 22 |
| Vaping (n) | — | 1 | — | 1 | — | 1 |
| Reported recreational THC use within the past 30 days (n) | 8 | 2 | 3 | 2 | 5 | 2 |
| Other substance use disorders (mild, lifetime, n) | 5 | 1 | 4 | 1 | 0 | 0 |
*Values are reported as mean (standard deviation) except where noted.
Abbreviations: PTSD-CC, person with PTSD who does not use nicotine; PTSD-NU, person with PTSD who currently uses nicotine; MDD-CC, person with MDD who does not use nicotine; MDD-NU, person with MDD who currently uses nicotine; CC, healthy person who does not use nicotine; NU, person without a known psychiatric diagnosis who currently uses nicotine; BDI, Beck Depression Inventory; MADRS, Montgomery-Åsberg Depression Rating Scale; FTND, Fagerström Test for Nicotine Dependence; QSU, Questionnaire of Smoking Urges; THC, tetrahydrocannabinol.
**Values are reported as mean (range).