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. 2023 Feb 21;13:3050. doi: 10.1038/s41598-023-30189-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic showing varying degrees of synaptic coverage by PsC. Three levels of PsC coverage represent the PsC in intimate contact with the synapse (A), when the PsC semi-wraps the synapse (B) and when the PsC is loosely coupled to the synapse (C). To simulate the various astrocyte-synapse couplings, the ECS volume and extracellular diffusion surface area is increased as the PsC moves away from the synapse.