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. 2023 Feb 21;13:3051. doi: 10.1038/s41598-023-28480-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of HALLMARK_EMT-related genes in mouse (stromal) and human (tumor parenchymal) tissues using PDX samples. Horizontal reference line indicates proportion of reads from stroma = 0.5 (signifying equal contribution from stromal and cancer cells to the estimated gene expression). Boxes extend from the first to third quartiles, the middle line shows the median, and the whiskers extend to the most extreme data point that is no more than 1.5 times the interquartile range from the box, open circles show individual values that are more than 1.5 times the interquartile range from the box. (a) Colon (n = 70). (b) Pancreatic (n = 57). (c) Ovarian carcinosarcoma (n = 4). Additional tumor types and gene sets are shown in Supplementary Fig. 2. These figures demonstrate that, for multiple tumor types, a greater proportion of transcripts of EMT-related genes were derived from stromal tissue than from tumor tissue, with the exception being the GENERIC_EMT_EPI_Tan_2014 gene set (shown in Supplementary Fig. 2f.).