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. 2023 Feb 20;11(2):e006121. doi: 10.1136/jitc-2022-006121

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Single-cell profile of escape tumor-infiltrating lymphocyte (TIL). (A) Uniform manifold approximation and projection (UMAP) dimensionality reduction of the single-cell RNA sequencing (scRNA-seq) data derived from the three indicated populations. The dashed outline delineates the sample each cell derived from. (B) Dot plot of gene expression of select cell-type gene markers. (C) Volcano plot of differentially expressed genes between Mutant Imp3-Specific TCR TransgenIC (MISTIC) T cells in Escape TIL and CD8+ T cells within control TIL.