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. Author manuscript; available in PMC: 2023 Aug 3.
Published before final editing as: Eur Respir J. 2022 Feb 3:2101032. doi: 10.1183/13993003.01032-2021

FIGURE 4.

FIGURE 4

The cytokine response to Pseudomonas aeruginosa infection is heightened in cystic fibrosis transmembrane conductance receptor knockout (KO) rats at both 2 and 6 months of age. Bronchoalveolar lavage fluid collected from wild-type (WT) and KO rats at 0, 3, 7, 14 and 28 days post-infection were analysed by ELISA for neutrophil elastase (NE) concentration in a) 2-month-old and b) 6-month-old rats; tumour necrosis factor (TNF)-α concentration in c) 2-month-old and d) 6-month-old rats; and interleukin (IL)-1β concentration in e) 2-month-old and f) 6-month-old rats. Data are presented as mean±sem and analysed via two-way ANOVA with Sidak post-test. *: p<0.05, **: p<0.01, ****: p<0.0001. n=6–8 per group.